Appropriate laboratory testing in Lyme disease

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Laboratory testing for Lyme disease: possibilities and practicalities.

Lyme disease (LD) is a multisystem and multistage infection caused by three species of tick-borne spirochetes in the Borrelia burgdorferi sensu lato genogroup. These include B. burgdorferi sensu stricto (North America and Western Europe), Borrelia afzelii (Western Europe, Central Europe, and Russia), and Borrelia garinii (Europe, Russia, and northern Asia). LD has become the most common vector-...

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Serologic Testing in Lyme Disease

Topic Overview: How should a clinician employ serologic tests in a Lyme disease evaluation? Before ordering an ELISA or Western blot the clinician should develop a clinical impression of the patient, taking into account the exposure history, symptoms and exam findings. If Lyme disease is judged to be a diagnostic possibility then testing is reasonable. Neither ELISA nor Western blot testing is ...

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Antibody Testing and Lyme Disease Risk

Lyme disease test results for >9,000 dogs were collected from participating veterinary clinics. Testing was conducted by using the IDEXX 3Dx kit, used widely by Maine veterinarians to screen clinically normal dogs during heartworm season. This study demonstrates how this test can be a valuable public health disease surveillance tool.

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Appropriateness of Lyme disease serologic testing.

BACKGROUND Although rapid diagnosis of Lyme disease is essential for effective treatment, there is concern about inappropriate testing. We conducted a prospective, cross-sectional survey of clinicians to assess the use and appropriateness of Lyme disease serologic tests (LDSTs). METHODS LDSTs performed at 2 large Wisconsin reference laboratories were systematically sampled for 12 consecutive ...

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Laboratory evaluation in the diagnosis of Lyme disease.

PURPOSE To provide a qualitative evaluation of the predictive value of the laboratory diagnosis of Lyme disease and to use the resultant data to formulate guidelines for clinical diagnosis. DATA SOURCES A MEDLINE search of English-language articles or articles with English-language abstracts published from 1982 to 1996. DATA EXTRACTION Sensitivity, specificity, and likelihood ratios were ca...

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ژورنال

عنوان ژورنال: Cleveland Clinic Journal of Medicine

سال: 2019

ISSN: 0891-1150,1939-2869

DOI: 10.3949/ccjm.86a.19029